A young couple Mira (Abbie Cobb) and Todd (Sean Faris) hire a live-in nurse (Lyndon Smith) to be the caregiver for their sick son, only to discover that she is an angel of death intent on replacing Mira through any means necessary.
Blood Sisters tells the story of two friends Sarah (Ini Dima-Okojie) and Kemi (Nancy Isime). Sarah is engaged to her dream man, Kola (Deyemi Okanlawon.) However, their seemingly idyllic union has a dark side.